![]() However, diseases which result in the official diagnosis of FUO are typically indolent, slowly progressive, or relatively occult. In theory, any inflammatory disease, including infectious, immune-mediated, and neoplastic diseases, may stimulate sufficient tumor necrosis factor-α and interleukin-1 and -6 production to result in persistent fevers. Similar specific criteria have not been accepted by veterinary internists however, using similar guidelines, most internists will define patients as having a fever of unknown origin if pyrexia persists beyond one to two weeks, physical examination prior to referral does not reveal any abnormalities, and the minimum data base fails to localize an underlying disease process to a particular organ system. Additional criteria are also occasionally suggested, such as presence of non-specific signs of illness, or hospitalization to ensure patient compliance with antibiotic administration. ![]() ![]() ![]() sufficient time for self-limiting infections to resolve) during which repeat physical examinations and standard diagnostic testing have failed to reveal an underlying cause. In human medicine, fever of unknown origin (FUO) is defined as pyrexia of greater than two to three weeks duration (i.e. ![]()
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